Clinical Trial: Impulsivity, Neural Deficits and Cocaine Addiction

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Impulsivity, Neural Deficits, and Relapse in Cocaine Addiction

Brief Summary: The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.

Detailed Summary: This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.
Sponsor: University of Texas Southwestern Medical Center

Current Primary Outcome:

  • Determine if the brain regions involved in inhibition and decision-making are altered in cocaine-addicted subjects compared to healthy controls. [ Time Frame: 2 weeks ]
  • In cocaine-addicted subjects, determine if neural deficits during disinhibition or decision-making are related to relapse following treatment. [ Time Frame: 6 months ]


Original Primary Outcome: Same as current

Current Secondary Outcome: Assess the predictive validity of self-report measures of impulsive relapse. [ Time Frame: 6 months ]

Original Secondary Outcome: Same as current

Information By: University of Texas Southwestern Medical Center

Dates:
Date Received: June 19, 2008
Date Started: April 2007
Date Completion:
Last Updated: December 31, 2012
Last Verified: December 2012