Clinical Trial: Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Comparative Effects of Single Dose Preemptive Gabapentin or Amitriptyline on Postoperative Pain and Opioid Consumption in Single Level Lumbar Laminectomy and Diskectomy: A Double Blind RCT With Placeb

Brief Summary: The hypothesis of this study is that Gabapentin or Amitriptyline has no role in preemptive analgesia to reduce postoperative pain after lumbar diskectomies.

Detailed Summary:

Pain suppression plays a decisive role in patients' satisfaction following lumbar diskectomies, as the psychological component of the pain is a major cause of treatment failure.

Controversy exists whether preemptive prescription of gabapentin, as a known contributor to reduce postoperative pain, has a role in patients undergoing laminectomy for lumbar diskectomy or spinal canal stenosis.The aim of this study is to test the efficacy of amitriptyline and gabapentin in this group of neurosurgical patients.

Sponsor: Tabriz University

Current Primary Outcome: 30% reduction in opium consumption in either study arms compared to the placebo group [ Time Frame: Within the first 24 hours after surgery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: 30% reduction in pain according to visual analogue scale in either study arms compared to the placebo group [ Time Frame: Within the first 24 hours after surgery ]

Original Secondary Outcome: Same as current

Information By: Tabriz University

Dates:
Date Received: November 14, 2009
Date Started: May 2009
Date Completion: March 2010
Last Updated: November 16, 2009
Last Verified: November 2009