Clinical Trial: Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients

Brief Summary: The alpha2 agonist dexmedetomidine is a new sedative agent combined with the analgesic qualities and lack of respiratory depression. Patients sedated with dexmedetomidine could be easily roused, these advances shows dexmedetomidine may be a effective and safe sedative agent. But some studies showed some adversely effects of dexmedetomidine on haemodynamics (such as bradycardia, hypotension), the investigators want to further research the effects of dexmedetomidine on haemodynamics, such as Cardiac Output (CO), Systemic Venous Resistance Index(SVRI), and so on. Propofol is widely used sedative agent in ICU, it also has adversely effects like bradycardia and hypotension, so the investigators want to compare the effect of dexmedetomidine with propofol on haemodynamics after major abdominal surgery. Expect to further research the mechanism of haemodynamics of dexmedetomidine.

Detailed Summary: When the patients can be roused, they will first receive analgesia with bolus of fentanyl 0.03mg, followed by a continuous infusion at a fixed dose of 0.3μg/kg/h during study period. Then patients will be randomly divided into two groups (Dexmedetomidine and Propofol). All of them will receive hemodynamic monitoring through "Vigileo"(Edwards Lifesciences) and cardiogram monitor. The study will continue for 6-24 hours.
Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Current Primary Outcome: Cardiac output [ Time Frame: the study will start when the patient can be roused after major abdominal surgery and will continue for 6 to 24hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Stroke Volume [ Time Frame: the study will start when the patient can be roused after major abdominal surgery and will continue for 6 to 24hours ]

Original Secondary Outcome: Same as current

Information By: First Affiliated Hospital, Sun Yat-Sen University

Dates:
Date Received: August 16, 2012
Date Started: May 2012
Date Completion: December 2012
Last Updated: August 20, 2012
Last Verified: August 2012