Clinical Trial: Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Procalcitonin Ratio's Impact on the Decision Upon On-demand Relaparotomy in Septic Peritonitis

Brief Summary: Procalcitonin (PCT) serum levels are monitored in patients with secondary peritonitis after initial operative focus elimination to investigate the PCT ratio's impact on decision-making for or against early relaparotomy in the on-demand relaparotomy concept of secondary septic peritonitis.

Detailed Summary:
Sponsor: CHIR-Net

Current Primary Outcome: prediction of focus elimination: cured patients versus patients with persisting peritonitis (definitions see below) [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 21 days ]

definition of 'focus elimination': patients with intestinal perforation or anastomotic leakage develop (local) peritonitis and consecutive abdominal sepsis. These patients need surgical intervention for focus elimination. This operative intervention aims to eradicate all infectious material and is intended to remove the leaking intestinal lesion. Whether this focus is eliminated or not can be controlled by either planned relaparotomy (normally within 48h after the first operation) or on demand relaparotomy in case of clinical deterioration. The focus can be assumed to be eliminated in all cases where either relaparotomy reveals no ongoing infection or persisting focus and whenever a patient recovers rapidly after initial surgery.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: CHIR-Net

Dates:
Date Received: January 10, 2013
Date Started: January 2009
Date Completion:
Last Updated: January 15, 2013
Last Verified: January 2013