Clinical Trial: Intracranial Aneurysms and Cognitive Function

Study Status: Active, not recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: Intracranial Aneurysms and Cognitive Function

Brief Summary: The prevalence rate of intracranial aneurysms in the adult population is close to 5%. Rupture risk of such aneurysms causing subarachnoid hemorrhage (SAH) can be substantial.Most patients suffering from an aneurysmal SAH are in their mid life, i.e., 30 to 60 years old. Aneurysmal SAH may cause disability and mortality. The present study includes a follow-up study and a cross-sectional fMRI study. The purpose of the follow-up study is to monitor patients receiving prophylactic surgical treatment of their un-ruptured aneurysms to examine whether such treatment is associated with cognitive, psychosocial and/or neurologic sequela. The purpose of the cross-sectional fMRI study is to examine the relationship between memory function and brain activity among SAH patients. Memory impairment is often found among aneurysmal SAH patients. Using fMRI can possibly shed some light on whether such memory impairment may be caused by diffuse cerebral damage or a focal damage at the aneurysm site.

Detailed Summary:
Sponsor: University Hospital of North Norway

Current Primary Outcome: Cognitive function [ Time Frame: Each subject will undergo one assessment of cognitive function. The assessment lasts about 2.5 hours including breaks. ]

Neuropsychological Assessment


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Neurological status [ Time Frame: Each subject will undergo one clinical assessment of neurological status. ]
    A clinical examination of neurological status
  • fMRI [ Time Frame: A subgroup of patients will participate in a fMRI study once ]
    A subgroup of patients will participate in a fMRI study once


Original Secondary Outcome: Same as current

Information By: University Hospital of North Norway

Dates:
Date Received: March 18, 2011
Date Started: March 2011
Date Completion: January 2014
Last Updated: May 11, 2012
Last Verified: May 2012