Clinical Trial: Screening Intracranial Aneurysms With Magnetic Resonance Angiography (MRA) in China

Study Status: Withdrawn
Recruit Status: Unknown status
Study Type: Observational

Official Title: Epidemiology of Cerebral Aneurysms With MRA in China in Middle-aged or Elder Person: a Population-based Survey

Brief Summary: The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population with MRA at 3.0 Tesla (T).

Detailed Summary:

Cerebral intracranial aneurysms are common. In angiographic and autopsy studies, estimates for prevalence vary between 0.2 and 9.9 percent. The methods used to detect the aneurysms markedly influenced the proportion of aneurysms. Retrospective autopsy studies probably give an underestimation and prospective angiography studies an overestimation of the actual prevalence. Accurate data on the prevalence of intracranial aneurysms are essential in evaluating the results of screening programs for aneurysms in general population.

During the past decade, MRA, as a preferred accuracy modality for noninvasive intracranial vascular imaging at most centers, is playing an increasing role in the evaluation of patients suspected of having intracranial aneurysms. In recurrent study, we have tested that MRA at 3T has excellent sensitivity, accuracy, and correlation with DSA and is comparable to catheter cerebral angiography for the evaluation of patients with intracranial aneurysms (Stroke, in press). Therefore, we examined trends in intracranial aneurysm prevalence with the use of MRA at 3.0T to determine the true prevalence of cerebral intracranial aneurysms in the general middle-aged or elder population.

Sponsor: Shanghai Jiao Tong University School of Medicine

Current Primary Outcome: Cerebral intracranial aneurysms identified by 3-D TOF-MRA at 3T [ Time Frame: 18 months after the study ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Suspected cerebral aneurysms detected by MRA underwent digital subtraction angiography (DSA) examination [ Time Frame: 32-36 months ]

Original Secondary Outcome: Same as current

Information By: Shanghai Jiao Tong University School of Medicine

Dates:
Date Received: June 19, 2009
Date Started: June 2007
Date Completion: June 2010
Last Updated: December 11, 2009
Last Verified: December 2009