Clinical Trial: Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis

Brief Summary:

Intracranial atherosclerotic disease (ICAD) is an important cause of ischemic stroke. The occurrence of stroke caused by symptomatic ICAD is significantly different compared with asymptomatic ICAD (19% vs 3.5%), suggesting that plaque vulnerability may be responsible for the difference. Based on the previous high-resolution magnetic resonance vessel wall imaging (HR-MRI) results, the investigators hypothesis that the feature of intracranial plaque enhancement is an important imaging biomarker of plaque instability, which is closely related to stroke. The investigators will establish the ICAD cohort and use HR-MRI to investigate the composition, morphology and the enhancement pattern of symptomatic ICAD plaques. These findings will correlate with biochemical markers, and stroke recurrence, in order to explore:

  1. plaque characteristics and the enhancement features between symptomatic ICAD and asymptomatic ICAD
  2. the relationship between plaque enhancement and the composition of plaques;
  3. relationship among enhancement features of symptomatic ICAD plaques, biomarkers with different clinical significance,
  4. evolution of enhancement features of symptomatic ICAD plaques under intensive medical therapy.

The investigators aim to explore the correlation between vulnerable plaque stratification and clinical outcomes, to explore the value of vascular responses in the pathogenicity of ICAD vulnerable plaques, as well as to provide objective basis for the establishment of the evaluation criteria of intracranial atherosclerotic vulnerable plaques.


Detailed Summary:

Detailed description:

Title: Vessel wall and Perfusion Imaging in Intracranial Atherosclerosis

Design: This is an prospective study that will study the characteristics of intracranial atherosclerotic plaque and the enhancement features of symptomatic ICAD during a mean follow-up of 1 year in symptomatic or asymtomatic patients with moderate to severe stenosis of middle cerebral artery(MCA).

In the WASID trail,patients with at least 70% stenosis of a major intracranial artery had an increased risk of recurrent stroke. However,The degree of stenosis is no longer the single predictor of vulnerable atherosclerotic lesions. Vulnerable plaques are closely associated with stroke recurrence.With the development of neurologic imaging, HR-MRI has unique ability to provide information on plaque compositions, plaque burden and vulnerable features. Several recent investigations suggest that enhancement of intracranial plaque is associated with recurrent stroke. However, no corhort study has been performed.

This prospective, multicenter trail will be conducted in China. Based on the previous work,participants will be divided into two groups :symtomatic ICAD and asymtomatic ICAD. Neurological examination and clinical sera testing will be performed at baseline, 1 month, 3 months, 6 months, and 12 months.The stroke incidence rate of asymptomatic ICAD and stroke recurrence rate of symptomatic ICAD will be recorded.


Sponsor: Xiuhai Guo

Current Primary Outcome: Stroke recurrence [ Time Frame: 1 year ]

the number of symptomatic participants who suffer from stroke recurrence after enrollment in the territory of the stenotic MCA.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Death [ Time Frame: 1 year ]
    The number of participants who suffer from death after enrollment
  • Any stroke, severe transient ischemic attack (TIA) outside the territory of symptomatic MCA [ Time Frame: at 7 days, 30 days,3 months，6 months, 12 months ]
    The number of participants who suffer from any stroke, severe transient ischemic attack (TIA) outside the territory of symptomatic MCA
  • Stroke of asymptomatic participants [ Time Frame: 1 year ]
    The number of asymptomatic participants who suffer from stroke after enrollment in the territory of the stenotic MCA；


Original Secondary Outcome: Same as current

Information By: Capital Medical University

Dates:
Date Received: March 16, 2016
Date Started: November 2015
Date Completion: September 2017
Last Updated: August 3, 2016
Last Verified: March 2016