Clinical Trial: A Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: A Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension

Brief Summary:

There is statistically significant correlation between invasive measures of intracranial pressure (ICP) and non-invasive, real-time, continuous physiologic waveform data algorithms to predict ICP. Furthermore, characteristics within this physiologic waveform data will allow modeling for trend prediction of derived ICP information. Specific aims:

  1. Develop models to estimate ICP and cerebral perfusion pressure (CPP) after traumatic brain injury in humans.
  2. Predict and anticipate changes in ICP for preemptive management purposes.
  3. Analyze characteristics of changes in ICP after treatment failure.
  4. Analyze data to predict/anticipate confounding physiologic factors that affect ICP and its treatment.
  5. Test the resulting models in real time.

Detailed Summary:
Sponsor: University of Colorado, Denver

Current Primary Outcome: Algorithm development [ Time Frame: 24 months ]

Developing algorithms relating data to intracranial pressure.


Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Colorado, Denver

Dates:
Date Received: October 5, 2011
Date Started: August 2011
Date Completion: November 2017
Last Updated: December 1, 2016
Last Verified: December 2016