Clinical Trial: Pituitary Function and Spontaneous Intracranial Hypotension

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension

Brief Summary: Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.

Detailed Summary:
Sponsor: Cedars-Sinai Medical Center

Current Primary Outcome: Comparing the levels of prolactin pre and post treatment [ Time Frame: 90 days ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Cedars-Sinai Medical Center

Dates:
Date Received: November 10, 2015
Date Started: July 2015
Date Completion: July 2019
Last Updated: January 30, 2017
Last Verified: January 2017