Clinical Trial: Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Utility of Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates

Brief Summary: Our overall aim is to examine if ultrasound is as accurate as MRI and/or CT in the evaluation of dural venous sinuses. We hypothesize that sonography will be accurate (accuracy >80%) for diagnosing specific anatomic findings of dural venous sinuses.

Detailed Summary:

Cranial ultrasound is an established technique for evaluation of the neonatal brain. However its role in the evaluation of cerebral dural venous sinuses in neonates has not been established. It is very important to evaluate the cerebral dural venous sinuses, as cerebral sinovenous thrombosis (CSVT) is an increasingly recognized condition in neonates.

There is an obvious clinical need for systematically evaluating the role of ultrasound with doppler in the evaluation of cerebral venous sinuses. Advances in diagnostic imaging have led to rapid clinical implementation of newer technologies like MR and CT for evaluation of venous sinuses. However technological advances in older imaging methods like ultrasound which have advantages of being non-invasive and being performed at the bedside have not been evaluated.

Sponsor: The Hospital for Sick Children

Current Primary Outcome: To prospectively evaluate the feasibility of visualization of normal dural venous sinuses, their patency, and normal variations with ultrasound in newborn children (preterm & term), using cross sectional imaging (MRI and/or CT) as reference standards. [ Time Frame: Within 10 hours of the MRI scan ]

Original Primary Outcome: Same as current

Current Secondary Outcome: The ability of doppler ultrasound to evaluate flow velocities in all dural venous sinuses that will be evaluated in this study. [ Time Frame: Within 10 hours of MRI ]

Original Secondary Outcome: Same as current

Information By: The Hospital for Sick Children

Dates:
Date Received: November 8, 2007
Date Started: May 2007
Date Completion:
Last Updated: May 19, 2015
Last Verified: May 2008