Clinical Trial: Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma
Brief Summary: Plaque radiotherapy is a common treatment for uveal melanoma. However, local failure has been reported in up to 20% of patients. We use intraoperative ultrasonography at plaque insertion and removal to evaluate plaque movement as a potential factor in local failure.
Detailed Summary: Episcleral plaque radiotherapy is a common treatment for uveal melanoma and results in local tumor control in most cases. However, local failure has been reported in a substantial proportion of patients. Since local failure greatly increases the risk of metastatic death, identifying and correcting the causes of local treatment failure are of paramount importance. Poor plaque localization is an important contributing factor to local failure. With the aid of intraoperative ultrasonography, most malpositioned plaques can be identified and readjusted at the time of plaque insertion. However, little is known about plaque movement during the 4-5 days of brachytherapy, which could also contribute to local failure. To address this question, we perform intraoperative B-scan ultrasonography at the time of iodine-125 radioactive plaque insertion and removal in uveal melanoma patients.
Sponsor: Barnes Retina Institute
Current Primary Outcome:
- Plaque tilt using intraoperative ultrasonography [ Time Frame: End of study ]
- Local melanoma failure [ Time Frame: End of study ]
Original Primary Outcome:
- Plaque tilt using intraoperative ultrasonography
- Local melanoma failure
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Barnes Retina Institute
Dates:
Date Received: April 11, 2007
Date Started: July 2000
Date Completion: July 2007
Last Updated: May 6, 2008
Last Verified: May 2008
