Clinical Trial: The Effects of Transversus Abdominis Plane Block in Patients Undergoing Total Abdominal Hysterectomy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Effects of TAP Block on Hemodynamic Variables, Anaesthetic and Analgesic Requirement and Quality of Recovery in Patients Undergoing Total Abdominal Hysterectomy

Brief Summary: The purpose of this study is to determine the effects of Transversus Abdominis Plane Block on hemodynamic variables, anaesthetic and analgesic requirement, and quality of recovery in patients undergoing total abdominal hysterectomy

Detailed Summary: Pain is one of the main causes of the poor perioperative outcomes and pain management is the important part of perioperative period. Neuraxial blocks could provide adequate analgesia during and after abdominal surgery. However,neuraxial blocks have a lot of contraindicated situations and neuraxial anesthesia can easily induce hemodynamic abnormalities. Therefore, in most cases, the choice of anaesthetic management may be the general anesthesia. In addition to reduce the blood pressure and heart rate changes due to surgical stimulations, the large amount of opioids and anaesthetics may be required. Opioid related side effects can affect perioperative complications and postoperative quality of recovery. Transversus abdominis plane block is a new choice to reduce postoperative pain in abdominal surgery. Although its postoperative analgesic efficacy is well known, its effects on hemodynamic variables, anaesthetic and analgesic requirement is not clear. The main objective of this study is to estimate the effect of Transversus abdominis plane block on hemodynamic variables, anaesthetic and analgesic requirement and quality of recovery in patients undergoing total abdominal hysterectomy.
Sponsor: Tokat Gaziosmanpasa University

Current Primary Outcome: intraoperative opioid consumption [ Time Frame: during anaesthesia ]

The overall intravenous remifentanyl consumption (microgram/ kilogram) during the surgery. The decision to administer remifentanyl is guided by the changes of blood pressure and/ or heart rate greater than 20% from baseline level.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Quality of recovery [ Time Frame: postoperative 24 hours ]
    quality of recovery 40 form will use to assessment the recovery
  • Postoperative nausea and vomiting [ Time Frame: postoperative 0.,2.,12.,24 hours ]
    nausea score(0-3) and number of vomiting will be recorded
  • postoperative pain [ Time Frame: postoperative 0,2,12,24 hours ]
    visual analog scale will be used
  • intraoperative hemodynamic variables [ Time Frame: during anaesthesia ]
    arterial blood pressure, heart rate changes will be recorded
  • intraoperative anaesthetic consumption [ Time Frame: during anaesthesia ]
    anaesthetic consumption will be calculated


Original Secondary Outcome: Same as current

Information By: Tokat Gaziosmanpasa University

Dates:
Date Received: November 13, 2014
Date Started: September 2014
Date Completion:
Last Updated: February 25, 2016
Last Verified: February 2016