Clinical Trial: Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: A Comparative Study on Clinical Efficacy of Clobetasol and Betamethasone in Orabase in Combination With Clotrimazole, in Oral Lichen Planus
Brief Summary: Oral Lichen Planus (OLP) is an autoimmune, chronic inflammatory mucocutaneous disease characterized by pain and burning sensation. The major types of OLP are the following: reticular, atrophic, erosive-ulcerative, bullous and pigmentous form.Its etiology remains unclear. The presence of auto-cytotoxic T cell clones in the lesions suggests the role of autoimmunity. Numerous treatment options of OLP include topical and systemic agents depending on severity of lesions . Topical corticosteroids abide the mainstay of therapy,and are widely accepted as the primary treatment of choice.Hence this study is designed to evaluate and compare the clinical efficacy of topical Clobetasol 0.05% in orabase and Betamethasone 0.05% in orabase in combination with Clotrimazole 1% in the management of symptomatic Oral Lichen Planus.
Detailed Summary:
Patients of either sex, irrespective of age attending the Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad who are clinically and histopathologically diagnosed with Oral Lichen Planus shall be included in the study group after obtaining an informed consent from the patients.
Study design: Prospective study.
Sample size:
A total of 30 patients will be randomly divided into 2 groups with 15 patients in each group.
Methodology:
30 patients who are diagnosed with Oral Lichen Planus by clinical and histopathological examination will be randomly assigned into 2 drug groups and burning sensation will be assessed by VAS Scale and also clinical improvement will be assessed at interval of 1 week till 4 weeks.
GROUP A: This group of patients will receive topical Clobetasol 0.05% in orabase and Clotrimazole 1%.
GROUP B: This group of patients will receive topical Betamethasone 0.05% in orabase and Clotrimazole 1%.
Inclusion criteria:
- Patients with Oral Lichen Planus, who are willing to participate in the study.
- Patients who are physically healthy and well oriented in time, space and as a person.
- Patients clinically and histopathologically diagnosed with Oral Lichen Planus.
- Patients with symptoms i.e. pain and burning sensation due to oral lichen planus.
Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Dates:
Date Received: January 17, 2017
Date Started: May 2016
Date Completion: December 2017
Last Updated: January 21, 2017
Last Verified: January 2017
