Clinical Trial: Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Acute Mesenteric Ischemia in the Emergency Department: Incidence, Early Recognition and Risk Stratification From an Observational Multicenter Study

Brief Summary: Acute mesenteric ischemia is a life-threatening condition characterized by high mortality if unrecognized early. This multicenter retrospective observational study will review the emergency departments's (ED) notes of all patients discharged from hospital with a diagnosis of acute mesenteric ischemia in 2014-2015 comparing it with those admitted to the ED for abdominal pain in the same timeframe.

Detailed Summary: Acute mesenteric ischemia is a condition characterized by non-specific presentation (typical clinical presentation is considered "abdominal pain out of proportion to examination") that may be under-recognized in the Emergency Department. Early identification and treatment is essential to improve outcome as mortality rate is attested around 80% if untreated within few hours from onset. The investigators aim to review the emergency department's clinical notes of patients discharged from hospital in 2014 and 2015 diagnosed with acute mesenteric ischemia. Furthermore the investigators will consider patients admitted for "abdominal pain" in the same time frame without acute mesenteric ischemia and we will compare presentation symptoms, medical history, medications, vitals, laboratory markers and imaging finding of the two groups. From this comparison, the investigators will be able to clarify the incidence among general population and among patients presenting acute abdominal pain. Finally, using multivariate analysis, the investigators may identify those variables predictive of acute mesenteric ischemia. This study will be held in three university hospitals and all data analyzed together.
Sponsor: University of Genova

Current Primary Outcome: In-hospital mortality [ Time Frame: 30 days from hospital admission ]

Original Primary Outcome: Same as current

Current Secondary Outcome: in-hospital adverse outcome: cardiac arrest, ICU admission, septic shock, major bleeding. [ Time Frame: 30 days from hospital admission ]

Original Secondary Outcome: Same as current

Information By: University of Genova

Dates:
Date Received: March 24, 2016
Date Started: August 2016
Date Completion: October 2017
Last Updated: May 2, 2017
Last Verified: May 2017