Clinical Trial: Evaluating Muscle Weakness Improvement With Lorcaserin in ICU
Study Status: Enrolling by invitation
Recruit Status: Enrolling by invitation
Study Type: Interventional
Official Title: Evaluating Lorcaserin Drug Therapy For ICU-Acquired Weakness: A Pilot Randomized Trial
Brief Summary: ICU acquired muscle weakness is a significant problem in patients recovering from critical illness. This trial will evaluate the safety and efficacy of a drug in improving muscle weakness in critically ill patients.
Detailed Summary:
Sponsor: Johns Hopkins University
Current Primary Outcome: Change in handgrip strength from baseline as measured by hand dynamometer [ Time Frame: 2 to 6 hours after administration of 30mg lorcaserin/placebo ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Change in handgrip strength from baseline as measured by hand dynamometer [ Time Frame: 2 to 6 hours after administration of 10mg lorcaserin/placebo ]
- Change in manual muscle strength from baseline as measured by the Medical Research Council (MRC) score [ Time Frame: 2 to 6 hours after administration of 30mg lorcaserin/placebo ]
- Change in manual muscle strength from baseline as measured by the Medical Research Council (MRC) score [ Time Frame: 2 to 6 hours after administration of 10mg lorcaserin/placebo ]
- Change in quadriceps strength from baseline as measured by handheld dynamometer [ Time Frame: 2 to 6 hours after administration of 30mg lorcaserin/placebo ]
- Change in quadriceps strength from baseline as measured by handheld dynamometer [ Time Frame: 2 to 6 hours after administration of 10mg lorcaserin/placebo ]
Original Secondary Outcome: Same as current
Information By: Johns Hopkins University
Dates:
Date Received: August 11, 2015
Date Started: September 2015
Date Completion:
Last Updated: August 29, 2016
Last Verified: August 2016
