Clinical Trial: Small Doses of Dexmedetomidine for Emergence Agitation

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Influence of Small Doses Dexmedetomidine to the Elderly Patients' Emergence Agitation

Brief Summary: Dexmedetomidine Hydrochloride is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, and reduce the adverse effects of stress reaction in anesthesia recovery period.Literatures have been reported that Dex can reduce the rate of emergence agitation of children and adults,especially in elderly patients(>64 years) after using sevoflurane anesthesia.

Detailed Summary:
Sponsor: Tang-Du Hospital

Current Primary Outcome:

  • evaluation of agitation [ Time Frame: the duration of PACU room stay,expect 30 minutes ]
    stay in the PACU room after operation,measure the score of Aono's four-point scale(AFPS) every two minutes.
  • evaluation of pain [ Time Frame: the duration of PACU room stay,expect 30 minutes ]
    stay in the PACU room after operation,measure the score of numeric rating scale(NRS) every two minutes.
  • the amount of drugs [ Time Frame: the duration of hospital stay,expect 5 weeks ]
    when stay in the hospital,measure the total doses of Nalbuphine and Fentanyl using
  • number of agitation [ Time Frame: the duration of hospital stay,expect 5 weeks ]
    when stay in the hospital, measure the number of agitation.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • the mean arterial pressure [ Time Frame: from the beginning of induction to skin closure, up to 1 hour ]
    measure the mean arterial pressure at 6 time points including after pump injection of Dexmedetomidine or normal saline 10 minutes, 20 minutes,30 minutes,before pulling out the endotracheal tube,at the time of pulling out the endotracheal tube,and after pulling out the endotracheal tube 5 minutes
  • heart rate [ Time Frame: from the beginning of induction to skin closure, up to 1 hour ]
    measure the heart rate at 6 time points including after pump injection of Dexmedetomidine or normal saline 10 minutes, 20 minutes,30 minutes,before pulling out the endotracheal tube,at the time of pulling out the endotracheal tube,and after pulling out the endotracheal tube 5 minutes


Original Secondary Outcome: Same as current

Information By: Tang-Du Hospital

Dates:
Date Received: May 26, 2014
Date Started: May 2014
Date Completion: October 2014
Last Updated: June 19, 2014
Last Verified: June 2014