Clinical Trial: Salivary Markers in Patients With Xerostomia
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]
Official Title: Oral Health and Salivary Markers in Patients With Xerostomia
Brief Summary: The purpose of this study was to investigate the salivary levels of inflammatory and their association with oral health in xerostomía patient
Detailed Summary:
Primary Outcome Measures:
- salivary Proinflammatory and anti-inflammatory cytokines
- questionnaire is provided to the patient for xerostomia characterization
Secondary Outcome Measures:
- Probing pocket depth
- Probing pocket depth and clinical attachment level
- Gingival index
- Plaque index
- Bleeding on probing
Sponsor: Universidad de Murcia
Current Primary Outcome:
- saliva flow rate [ Time Frame: 2 months ]Unstimulated salivary flow rate. Pathological < or 1.5 ml/ 15 minutes.
- Xerostomia [ Time Frame: 2 months ]Visual Analogue Scale (VAS) for xerostomia severity (0 cm: no xerostomía , 10cm : very severe xerostomia ).
- Interleukins [ Time Frame: 2 months ]Analytes in saliva IFN-(pg/ml), IL-10(pg/ml), IL-1b(pg/ml), IL-4 (pg/ml)and IL-6 (pg/ml)
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Oral Exam [ Time Frame: 4 months ]Caries number, natural teeth number
- Periodontal evaluation [ Time Frame: 4 months ]periodontal( gingival index, bleeding index, clinical attachment level, probing depth,number dental implant .A periodontal probe will be inserted between the tooth and the gum in the gingival sulcus and a measurement of the pocket depth will be measured by a trained dentist in all subjects according to American Academy of Periodontology classification of periodontal diagnosis
Original Secondary Outcome: Same as current
Information By: Universidad de Murcia
Dates:
Date Received: May 1, 2017
Date Started: January 2016
Date Completion: July 2017
Last Updated: May 15, 2017
Last Verified: May 2017