Clinical Trial: Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma

Brief Summary: The purpose of this study is the investigation of new host-microbiome interactions promoting adenoma formation and adenocarcinoma progression. For that purpose, the investigators will collect saliva, stool and colon biopsy specimens from patients referred to colonoscopy or surgical resection of colorectal tumor. Besides, a questionnaire about diet, lifestyle and medical history will be collected. Sample analysis will involve simultaneous characterization of host and microbiota genomic and transcriptomic components.

Detailed Summary:
Sponsor: Universitaire Ziekenhuizen Leuven

Current Primary Outcome: Differential host microbiome composition and abundance in healthy, adenoma and CRC patients and its correlation to CRC risk features and host genomic and transcriptomic components. [ Time Frame: 2 years ]

Host microbiome composition and abundance data will be generated from saliva, stool and colonic biopsies with amplicon-based 16S ribosomal RNA sequencing. This data will be correlated to CRC risk factors collected in a questionnaire covering lifestyle, diet and medical history as well as host genomic and transcriptomic profiling generated by targeted gene sequencing and microarray-based gene expression profiling.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Universitaire Ziekenhuizen Leuven

Dates:
Date Received: October 13, 2016
Date Started: July 2016
Date Completion:
Last Updated: December 12, 2016
Last Verified: August 2016