Clinical Trial: Comparing the ADR With Air Insufflation, Water Immersion and Water Exchange During Two-endoscopist Colonoscopy

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: A Randomized, Controlled Trial Comparing the Adenoma Detection Rate With Air Insufflation, Water Immersion and Water Exchange During Two-endoscopist Colonoscopy

Brief Summary: Interval (missed) cancers and lower than expected mortality reduction of proximal colon cancers in the United States and elsewhere after screening colonoscopy drew attention to quality indicators. Missed adenomas which are more likely to be in the proximal colon may be contributing factors. An independent predictor of the risk of interval cancers is adenoma detection rate. In pilot observations, the investigators showed that water exchange enhanced adenoma detection in the right colon (cecum to hepatic flexure). This prospective, randomized controlled trial will compare water exchange with water immersion and traditional air insufflation in patients undergoing colonoscopy. The investigators test the hypothesis that compared with air insufflation and water immersion, water exchange produces a significantly higher adenoma detection rate in the right colon

Detailed Summary: All of the procedures will be recorded and stored as digital files.
Sponsor: Dalin Tzu Chi General Hospital

Current Primary Outcome: adenoma detection rate in the right colon [ Time Frame: one week ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • overall adenoma detection rate [ Time Frame: one week ]
  • post-procedure discomfort [ Time Frame: 1 day after colonoscopy ]
    pain or distention on a 0 to 10 VAS scale
  • 30 days complication rate [ Time Frame: 30 days ]
    incidence of bleeding, perforation and unexpected admission


Original Secondary Outcome: Same as current

Information By: Dalin Tzu Chi General Hospital

Dates:
Date Received: August 25, 2015
Date Started: December 2015
Date Completion: December 2017
Last Updated: April 8, 2016
Last Verified: February 2016