Clinical Trial: Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.

Brief Summary: The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy. Patients will be randomized to either conventional colonoscopy or chromocolonoscopy, where the entire colon will be sprayed with indigocarmine dye and examined in the usual manner. The primary outcome will be the total number of adenomas detected, with special attention to the subgroup of flat and depressed lesions. To promote the generalizability of the results, neoplasms will be described according to standard Western and Japanese classification schemes.

Detailed Summary:
Sponsor: Indiana University

Current Primary Outcome: Prevalence of adenomas detected by chromocolonoscopy versus standard colonoscopy. [ Time Frame: Cross-sectional prevalence of adenomas between the 2 study groups ]

Original Primary Outcome: Prevalence of adenomas detected by chromocolonoscopy versus standard colonoscopy.

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Indiana University

Dates:
Date Received: October 26, 2005
Date Started: May 2006
Date Completion:
Last Updated: January 27, 2009
Last Verified: January 2009