Clinical Trial: Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism

Brief Summary: Our main objective is to assess whether aortic stiffness is a predictor of blood pressure response after surgery in patients with an aldosterone producing adenoma or a unilateral adrenal hyperplasia.

Detailed Summary: Secondary objectives are to investigate whether aortic stiffness predicts cardiovascular , operative and postoperative morbid-mortality at 1 year, to evaluate the benefit of adrenalectomy in patients with primary aldosteronism due to unilateral adrenal hyperplasia and in patients with aldosterone producing adenoma associated with controlateral adrenal morphological abnormalities, and to participate to a national DNA repository of patients with primary aldosteronism.
Sponsor: University Hospital, Toulouse

Current Primary Outcome: Responders to surgery, patients not receiving aldosterone antagonists, with mean-24h-ABP < 130/80 mmHg with or without antihypertensive treatment [ Time Frame: 2 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Day-time and night-time ABP and circadian BP variability, number of antihypertensive agents at 1 year after surgery, prediction of post-operative complications, prediction of cardiovascular morbidity at 1 year. [ Time Frame: 2 years ]

Original Secondary Outcome: Same as current

Information By: University Hospital, Toulouse

Dates:
Date Received: August 25, 2010
Date Started: June 2009
Date Completion:
Last Updated: February 21, 2017
Last Verified: February 2017