Clinical Trial: Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer
Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational
Official Title: Prevalence of Colorectal Adenoma in 30- to 49-year-old Asymptomatic Subjects With a First Relative History of Colorectal Cancer
Brief Summary:
Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer are controversial. The aim of this study was to prospectively define the prevalence of colorectal adenoma 30- to 49-years-old asymptomatic subjects with a first relative history of colorectal cancer and to compare the data with controls.
Design: Single-center prospective study
Detailed Summary: Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer).
Sponsor: Asan Medical Center
Current Primary Outcome: prevalence of colorectal adenoma(any size) [ Time Frame: First screening colonoscopy ]
Original Primary Outcome: prevalence of colorectal adenoma(any size) and advanced adenoma [ Time Frame: First screening colonoscopy ]
Current Secondary Outcome: prevalence of advanced adenoma [ Time Frame: First screening colonoscopy ]
- Any adenoma ≥10 mm
- Any villous component
- High-grade dysplasia
Original Secondary Outcome: prevalence of colorectal cancer [ Time Frame: First screening colonoscopy ]
Information By: Asan Medical Center
Dates:
Date Received: September 2, 2011
Date Started: September 2011
Date Completion: September 2014
Last Updated: September 8, 2011
Last Verified: September 2011