Clinical Trial: Observational Study of Biomarker During Liver Surgery

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Autophagy in Liver Injury: Changes in Autophagy Biomarkers During Liver Surgery

Brief Summary: The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver diseases.

Detailed Summary: If asked to participate in this research study, it is because a liver resection/liver transplantation surgery has been scheduled. During the procedure a small section will be collected for additional testing of Sirtuin 1. In addition, information concerning the liver disease, laboratory and pathology results after surgery will be collected by the investigators.
Sponsor: University of Florida

Current Primary Outcome: Biochemical analysis of sirtuin1 from liver tissues during liver surgery [ Time Frame: 30 minutes during liver surgery ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Florida

Dates:
Date Received: March 31, 2014
Date Started: October 2014
Date Completion: December 2019
Last Updated: March 15, 2017
Last Verified: March 2017