Clinical Trial: Effects the Glycemic Index on Metabolic Risk Markers

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Postprandial Effects of a Low vs. a High Glycemic Index Food Product on Metabolic Risk Markers in Lean and Obese Subjects

Brief Summary: Recent population studies have shown that the glycemic index (GI) of food products is positively associated with the risk of developing type 2 diabetes and cardiovascular disease (CVD). In the pathogenesis of type 2 diabetes and CVD, inflammatory processes play a pivotal role. In a previous intervention study (11 weeks), however, we found no effects of lower-GI vs. higher-GI diets on fasting inflammatory markers in subjects with increased risk of developing the metabolic syndrome. People, however, spent most of their time in the postprandial period. Therefore, there is a need to study the postprandial effects of low-GI vs. high-GI diets. In addition, it needs to be emphasized the GI is derived from studies in lean subjects, while especially overweight and obese people suffer from metabolic aberrations related to the development of type 2 diabetes and CVD. AIM: To investigate in obese subjects the postprandial effects of a low-GI vs. high-GI food product on metabolic risk markers. A second research objective is to compare these effects with those in lean subjects.

Detailed Summary:
Sponsor: Maastricht University Medical Center

Current Primary Outcome: inflammation markers [ Time Frame: postprandial effect ]

Original Primary Outcome: Same as current

Current Secondary Outcome: glucose response [ Time Frame: postprandial ]

Original Secondary Outcome: Same as current

Information By: Maastricht University Medical Center

Dates:
Date Received: June 4, 2008
Date Started: February 2008
Date Completion: December 2008
Last Updated: December 11, 2008
Last Verified: December 2008