Clinical Trial: The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Obtaining Early Diagnosis and Prognosis in Urgent Sepsis (OEDIPUS) Study

Brief Summary:

Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies. Blood cultures are often negative in neutropenic patients because of low-burden of organisms, previous antibiotic therapy or non-infectious reason of fever. More rapid, accurate and sensitive diagnostic tools are needed.

Hypothesis: Multiplex real-time PCR may detect microbial DNA in neutropenic patients before febrile episode. To investigate this hypothesis, EDTA-blood was routinely collected for multiplex PCR at admission and 3x/week thereafter until discharge or recovery from neutropenia

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire Vaudois

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Centre Hospitalier Universitaire Vaudois

Dates:
Date Received: August 16, 2012
Date Started: November 2007
Date Completion:
Last Updated: August 17, 2012
Last Verified: August 2012