Clinical Trial: fMRI Guided TMS Enhancement of Associative Memory Networks

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: A Randomized Controlled Pilot Study of TMS Enhancement of Associative Memory Networks in Healthy Subjects and Epilepsy Patients

Brief Summary: This is a randomized, single-blinded, controlled phase 1 study to demonstrate feasibility and explore the neurophysiologic and clinical effects of repetitive transcranial magnetic stimulation (TMS) interventions in epilepsy patients and healthy controls. The inclusion of a control group will be used to see whether epilepsy patients, who suffer from a higher degree of comorbid memory difficulty presumably from entorhinal-hippocampal dysfunction, can benefit from a TMS intervention can benefit as much as a healthy matched population. Investigators will also be looking at functional connectivity between the hippocampus and cortical regions

Detailed Summary:
Sponsor: New York University School of Medicine

Current Primary Outcome:

  • Resting state fMRI to assess stimulation-induced changes in connectivity. [ Time Frame: Week 2, Week 5 ]
  • Change in score on cognitive testing face recognition task [ Time Frame: Week 2, Week 5 ]
  • Montreal Cognitive Assessment (MOCA) [ Time Frame: 5-6 Weeks ]
    cognitive screening test designed to assist Health Professionals for detection of mild cognitive impairment
  • Seizure Diary [ Time Frame: Up to Week 6 ]


Original Primary Outcome:

  • Resting state fMRI to assess stimulation-induced changes in connectivity. [ Time Frame: Week 2, Week 4 ]
  • Change in score on cognitive testing face recognition task [ Time Frame: 5 Weeks ]
  • Montreal Cognitive Assessment (MOCA) [ Time Frame: 4 Weeks ]
    cognitive screening test designed to assist Health Professionals for detection of mild cognitive impairment
  • Seizure Diary [ Time Frame: Up to Week 5 ]


Current Secondary Outcome:

Original Secondary Outcome:

Information By: New York University School of Medicine

Dates:
Date Received: April 13, 2016
Date Started: October 2016
Date Completion: November 2017
Last Updated: February 27, 2017
Last Verified: February 2017