Clinical Trial: Exercise Treatment of Mild-Stage Probable Alzheimer's Disease
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Physical Activity as a Treatment of Mild-Stage Probable Alzheimer's Disease
Brief Summary: The purpose of the study is to determine if participation in an exercise program helps memory loss from getting worse, and if it improves daily functioning and attitudes of those with probable Alzheimer's disease. It will involve participation of both the person with memory loss and someone who knows their daily activities (e.g., husband, wife, adult child, or caregiver).
Detailed Summary:
Currently, there is no cure for the memory loss associated with Alzheimer's disease, though some medications can help it from getting worse. The research study will help to answer the question if participation in an exercise program helps memory loss from getting worse, and if it improves daily functioning and attitudes of those with probable Alzheimer's disease. It will involve participation of both the person with memory loss and someone who knows their daily activities.
The research study is a randomized-control trial: some participants will be picked to participate in the exercise program, while others will not. Their memory, thinking abilities, activities, and attitudes will be measured at baseline and follow-up assessment 5-6 months later. Participants are in good health, and are treated with a cholinesterase inhibitor for memory loss (standard treatment).
Sponsor: Intermountain Health Care, Inc.
Current Primary Outcome:
- For the intervention group: Change in cognitive performance relative to baseline [ Time Frame: baseline & 20 week follow-up ]
- Group differences in cognitive performance following intervention and relative to wait-list control group [ Time Frame: baseline & 20 week follow-up ]
- For the intervention group: Change in attitudes, including self-report of well-being and cognitive abilities relative to baseline [ Time Frame: baseline & 20 week follow-up ]
- Group differences in attitudes, including self-report of well-being, following intervention and relative to wait-list control group [ Time Frame: baseline & 20 week follow-up ]
Original Primary Outcome:
- For the intervention group: Change in cognitive performance relative to baseline
- Group differences in cognitive performance following intervention and relative to wait-list control group
- For the intervention group: Change in attitudes, including self-report of well-being and cognitive abilities relative to baseline
- Group differences in attitudes, including self-report of well-being, following intervention and relative to wait-list control group
Current Secondary Outcome:
- For the intervention group: Change in knowledgeable informant's ratings of function, behavior, and attitudes [ Time Frame: baseline & 20 week follow-up ]
- Group differences in knowledgeable informant's ratings of function, behavior, and attitudes following intervention and relative to wait-list control group [ Time Frame: baseline & 20 week follow-up ]
Original Secondary Outcome:
- For the intervention group: Change in knowledgeable informant's ratings of function, behavior, and attitudes
- Group differences in knowledgeable informant's ratings of function, behavior, and attitudes following intervention and relative to wait-list control group
Information By: Intermountain Health Care, Inc.
Dates:
Date Received: November 21, 2006
Date Started: October 2006
Date Completion:
Last Updated: May 9, 2011
Last Verified: November 2006
