Clinical Trial: Sleep Quality and Amyloid-Beta Kinetics
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Sleep Quality and Amyloid-Beta Kinetics
Brief Summary: The purpose of this study is to change the concentration of amyloid-beta in human cerebrospinal fluid (CSF) by modification of sleep efficiency.
Detailed Summary: The purpose of the study is to investigate whether or not increasing sleep efficiency will change the concentration of amyloid-beta in cerebrospinal fluid (CSF).
Sponsor: Washington University School of Medicine
Current Primary Outcome: Change in Amyloid-beta (Abeta) production, clearance, and concentration in the CSF (cerebral spinal fluid) of individuals with poor sleep efficiency as measured by ng/ml. [ Time Frame: 36 hours of CSF collection ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Change in Amyloid-beta (Abeta) production, clearance, and concentrations in the CSF (cerebral spinal fluid) following pharmacologic sleep induction.induction in individuals with poor sleep efficiency. [ Time Frame: 36 hours of CSF collection ]
Original Secondary Outcome: Same as current
Information By: Washington University School of Medicine
Dates:
Date Received: October 17, 2016
Date Started: November 2016
Date Completion: June 2019
Last Updated: March 6, 2017
Last Verified: March 2017