Clinical Trial: Modulation of CSF Amyloid-beta Concentrations Via Behavioral Sleep Deprivation and Pharmacological Sleep Induction

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Modulation of CSF Amyloid-beta Concentrations Via Behavioral Sleep Deprivation and Pharmacological Sleep Induction

Brief Summary: The purpose of this study is to change the concentration of amyloid-beta in human cerebrospinal fluid (CSF) through modulation of the sleep-wake cycle.

Detailed Summary: The purpose of this research study is to investigate whether or not increasing or decreasing duration of sleep over one night will change the concentration of amyloid-beta in cerebral spinal fluid (CSF).
Sponsor: Washington University School of Medicine

Current Primary Outcome: Change in CSF amyloid beta concentration during sleep induction and sleep deprivation [ Time Frame: 36 hours of CSF collection ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Washington University School of Medicine

Dates:
Date Received: January 29, 2014
Date Started: December 2013
Date Completion:
Last Updated: March 6, 2017
Last Verified: March 2017