Clinical Trial: 11C-ACETATE PET/CT IMAGING AS A MARKER OF AMYLOID-INDUCED NEUROINFLAMMATION

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: 11C-ACETATE PET/CT IMAGING AS A MARKER OF AMYLOID-INDUCED NEUROINFLAMMATION

Brief Summary: Our proposed study aims to use 11C-acetate PET/CT to preliminarily test and validate methods for imaging astrocyte activation as an early indicator of neuroinflammation in Alzheimer's disease (AD). 11C-Acetate PET/CT has been shown to quantify astrocyte activation in vivo, but no reports have evaluated its potential in AD. We propose to test 11C-Acetate PET/CT as a marker for astrocyte activation associated with pathologic amyloid deposition in AD. We will compare binding between subjects with early stage AD and healthy controls. Further, we will investigate the correlation between amyloid and acetate binding. If we find increased astrocyte activation in response to cerebral amyloid by showing a group difference in brain acetate uptake between disease and controls or a strong correlation between acetate and amyloid PET/CT binding. Validating neuroinflammation markers in AD ultimately may guide therapeutic modulation of beneficial and damaging neuroinflammation to slow disease progression, as well as providing new insights into AD pathophysiology.

Detailed Summary:
Sponsor: University of Pennsylvania

Current Primary Outcome: Evaluate whether 11C-acetate uptake is increased in amyloid positive Mild Cognitive Impairment (MCI) subjects compared to amyloid negative healthy controls [ Time Frame: 7 days ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Correlate 11C-acetate uptake to areas of greater amyloid plaque burden quantified on Amyloid PET/CT [ Time Frame: 7 days ]
  • Compare 11C-acetate in areas of mildly elevated PET SUVR to areas with high or sub-threshold amyloid burden [ Time Frame: 7 days ]
  • Correlate 11C-acetate uptake to levels of inflammatory markers in CSF [ Time Frame: 7 days ]


Original Secondary Outcome: Same as current

Information By: University of Pennsylvania

Dates:
Date Received: June 20, 2016
Date Started: June 2016
Date Completion:
Last Updated: June 20, 2016
Last Verified: June 2016