Clinical Trial: Mediastinal Microdialysis in Patients With Oesophageal or Cardia Cancer Treated by Resection

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Mediastinal Microdialysis in Early Diagnosis of Anastomotic Leakage After Resection for Esophageal Cancer: Preliminary Results

Brief Summary: Postoperative anastomotic leakage is a serious complication in patients with oesophageal or cardia cancer. Early diagnosis and treatment are mandatory. The primary aim of the present study is to investigate the clinical use of mediastinal microdialysis and whether is able to detect anastomotic leakage prior to the development of clinical symptoms.

Detailed Summary:

Patients undergoing oesophageal or cardia resection for cancer are monitored by mediastinal microdialysis during the postoperative period. Subcutaneous microdialysis serves as a control. Samples are collected every 4-hour. Samples will be analyzed continuously but the results will not be included in the clinical evaluation of the patient.

A total of 30 patients will be included in this pilot study. The results of the mediastinal microdialyses will be compared with the clinical course in each patient. The results form the uncomplicated courses will be used to define the normal variations in mediastinal microdialysis. This will be compared to results from patients with various complications.

Sponsor: Odense University Hospital

Current Primary Outcome: Early detection of postoperative complications [ Time Frame: 30 days postoperative ]

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Odense University Hospital

Dates:
Date Received: May 27, 2008
Date Started: April 2007
Date Completion:
Last Updated: August 3, 2014
Last Verified: August 2014