Clinical Trial: Cervical Rippening With Antiprogesterone in Midtrimester Abortions
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Cervical Rippening With Antiprogesterone in Midtrimester Abortions
Brief Summary: Induction of midtrimester abortion includes cervical ripening and then contraction to induce uterine evacuation. There are several protocols, but most of them include using prostaglandins (PG). The disadvantages of using PG include uncomfortable side effects and limits of using it for women after cesarean section. Mifepristone is an antiprogesterone drug and been used for induction of abortion in first and second trimesters abortions. The aim of this study is to explore the effectiveness of Mifepristone for cervical ripening before high dose Oxytocin drip.
Detailed Summary: The aim of this study is to explore the effectiveness of Mifepristone for cervical ripening before high dose Oxytocin drip in midtrimester abortions. After informed consent, all the women will be randomized for Mifepristone or placebo. 48 hours later, high dose oxytocin drip will be started and we will examine the success rate to induce abortion, the duration from starting oxytocin till evacuation of uterus and side effects.
Sponsor: Hadassah Medical Organization
Current Primary Outcome:
- success of abortion induction
- abortion induction duration
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Hadassah Medical Organization
Dates:
Date Received: December 11, 2006
Date Started: August 2004
Date Completion:
Last Updated: February 28, 2017
Last Verified: May 2008
