Clinical Trial: Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Association Between Interleukin-10 Promoter-1082A/G Polymorphism With Idiopathic Recurrent Miscarriage Risk of Chinese Han

Brief Summary: This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han. A total of 100 women with IRM and 100 control women with a successful pregnancy will be included in this study. Then genotyping will be performed.

Detailed Summary:

As a common occurrence in early pregnancy, IRM has been associated with multiple causes, among which the disorders of immune homeostasis between the fetus and the maternal immune system, maintained by cytokines from the complex regulatory network, are considered one of the potential etiological factors underlying IRM.

The IL-10 polymorphism -1082A/G (rs1800896), which is located in the promoter region of the IL-10 gene, was reported to be implicated in the abnormal expression of IL-10 in IRM by some studies.

However, no such reports about the association between IL-10 polymorphism -1082A/G and IRM risk in Chinese Han.

Sponsor: Fourth Affiliated Hospital of Guangxi Medical University

Current Primary Outcome: genetic polymorphisms associated with idiopathic recurrent miscarriage [ Time Frame: within one year (plus or minus 1 month) after surgery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Indexes in the routine blood test and blood coagulation test [ Time Frame: During pregnancy and three months after miscarriage ]

Original Secondary Outcome:

Information By: Fourth Affiliated Hospital of Guangxi Medical University

Dates:
Date Received: December 11, 2015
Date Started: August 2015
Date Completion: December 2017
Last Updated: February 14, 2017
Last Verified: February 2017