Clinical Trial: Hereditary AngioEdema, Neurobiology and Psychopathology

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational [Patient Registry]

Official Title:

Brief Summary: Since 1963 Hereditary AngioEdema (HAE) is considered an autosomal dominant disorder (Donaldson and Evans), characterized by a quantitative and/or qualitative deficit of C1 esterase inhibitor (C1-INH), which affects approximately 1:50.000 individuals in the general population. From this period the link between HAE and psychiatry was interrupted, however genetic issues could not comprehensively explain the clinical evolution of the disease. Clinical studies show an evident gap between genotype and phenotype of HAE. For this still controversial question, we have designed this cross-sectional study in order to establish the relationship between HAE clinical manifestations and neurobiological/psychopatological parameters.

Detailed Summary:
Sponsor: University Hospital, Catania

Current Primary Outcome: Multivariate linear regression analysis of HAE clinical status and psychometric parameters [ Time Frame: First assessment ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Catania

Dates:
Date Received: June 5, 2014
Date Started: November 2014
Date Completion: May 2015
Last Updated: June 5, 2014
Last Verified: June 2014