Clinical Trial: Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic

Brief Summary: We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.

Detailed Summary:

Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.

The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.

Sponsor: Luzerner Kantonsspital

Current Primary Outcome: Quality of cardiac imaging in computed tomography [ Time Frame: After comparison of imaging measurements ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Luzerner Kantonsspital

Dates:
Date Received: October 3, 2008
Date Started: May 2007
Date Completion:
Last Updated: April 16, 2013
Last Verified: April 2013