Clinical Trial: The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury
Brief Summary: This is a double-blind, placebo-controled, randomized trial to investigate if aspirin pre-treatment has anti-inflammatory effects in a model of acute lung injury induced by inhaled endotoxin (LPS) in healthy human volunteers.
Detailed Summary:
Sponsor: Belfast Health and Social Care Trust
Current Primary Outcome: Bronchoalveolar lavage IL-8 concentration [ Time Frame: 6 hrs after LPS inhalation ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Alveolar inflammatory response biomarkers [ Time Frame: 6 hrs after LPS inhalation ]
- Plasma inflammatory response biomarkers [ Time Frame: 6 and 24 hrs after LPS inhalation ]
- Alveolar epithelial and endothelial function and injury biomarkers [ Time Frame: 6 hrs after LPS inhalation ]
- Lipid inflammatory mediators [ Time Frame: 6 and 24 hrs after LPS inhalation ]
Original Secondary Outcome: Same as current
Information By: Belfast Health and Social Care Trust
Dates:
Date Received: August 4, 2012
Date Started: September 2012
Date Completion: August 2017
Last Updated: February 4, 2017
Last Verified: February 2017
