Clinical Trial: Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Association Study of Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery With Cardiopulmonary Bypass

Brief Summary: Acute lung injury is a common complication of cardiac surgery with cardiopulmonary bypass, and it is significantly related to prolonged postoperative recovery, hospital stays and medical cost. Currently available predictors of acute lung injury after cardiac surgery are still limited within clinical data. Several genetic polymorphism of inflammatory mediators have been reported to be associated with severity of sepsis and ARDS, but the association of these inflammatory polymorphism and acute lung injury after cardiac surgery has never been reported. This study is performed to investigate the association of genetic polymorphisms including TNF -308A/G, IL-10 -1082A/G and IL-6 -572C/G and postoperative lung injury.

Detailed Summary:
Sponsor: Changhai Hospital

Current Primary Outcome: Acute lung injury after cardiac surgery with cardiopulmonary bypass [ Time Frame: 24h after surgery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: circulating level of CRP, TNF-alpha, IL-10, IL-6; APACHE Ⅱ score; postoperative kidney injury, duration of ventilation, ICU stay and hospitalization; death in 28 days [ Time Frame: 24h and 1 month after surgery ]

Original Secondary Outcome: Same as current

Information By: Changhai Hospital

Dates:
Date Received: January 20, 2009
Date Started: May 2008
Date Completion:
Last Updated: May 2, 2013
Last Verified: May 2013