Clinical Trial: Studying Genes in Samples From Younger Patients With Adrenocortical Tumor
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0
Brief Summary:
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.
Detailed Summary:
OBJECTIVES:
- To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells.
OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.
Sponsor: Children's Oncology Group
Current Primary Outcome:
- Identification of genetic factors affecting adrenocortical tumors
- Comprehensive catalog of altered genes in adrenocortical samples
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Children's Oncology Group
Dates:
Date Received: February 5, 2012
Date Started: February 2012
Date Completion:
Last Updated: May 17, 2016
Last Verified: May 2016
