Clinical Trial: Optimizing Diagnosis Of Primary Aldosteronism

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Case Detection and Confirmation, Subtype Classification of Patients With Primary Aldosteronism

Brief Summary: To optimize the confirmatory tests for primary aldosteronism.

Detailed Summary: In this study, the investigators aim to optimize the three confirmatory tests: salt loading, captopril challenge and fludrocortisone suppression, and to confirm a better choice of confirming testing for single or combined diagnosis of primary aldosteronism. Additionally, the investigators plan to collect blood and tissue samples of PA patients for genetic testing, and to proceed a long-term follow-up for further investigating the mechanism underlying PA and evaluating the cardio-cerebrovascular complications risk.
Sponsor: Chongqing Medical University

Current Primary Outcome:

• Area under the receiver operating characteristic curve (AUC) for Salt loading test [ Time Frame: 1 week ]
  Salt loading test will be performed and compared to golden standard such as adrenal venous sampling (AVS) and biopsy results. The area under the curve (AUC) will be calculated.
• AUC for captopril challenge test [ Time Frame: 1 week ]
  Captopril challenge test will be performed and compared to golden standard such as AVS and biopsy results. AUC will be calculated.
• AUC for fludrocortisone suppression test [ Time Frame: 1 week ]
  Fludrocortisone suppression test will be performed and compared to golden standard such as AVS and biopsy results. AUC will be calculated.

Original Primary Outcome: Same as current

Current Secondary Outcome: Incidence of cardiovascular diseases in Primary Aldosteronism [ Time Frame: 3 years ]

Original Secondary Outcome: Same as current

Information By: Chongqing Medical University

Dates:
Date Received: April 8, 2016
Date Started: May 2014
Date Completion:
Last Updated: November 10, 2016
Last Verified: November 2016