Clinical Trial: HPV as a Possible Cause of Azoospermia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title:

Brief Summary:

Azoospermia is found in 5-20% of all men suffering from infertility, and in more than 20% azoospermia remains unexplained. The investigators suggest, that HPV may be an etiological factor in azoospermia and reduced sperm production.

The investigators plan to examine the occurrence of HPV in testicular tissue from 100 azoospermic men and to compare with the HPV occurrence in testicular tissue from a control group of 40 normal, healthy men undergoing vasectomy. Since HPV, in a recent Danish study, was detected on sperm in 16% of 188 randomly selected semen donors, the investigators also plan to examine the occurrence of HPV on sperm ejaculated during the last week before vasectomy. If HPV should be found in testicular tissue from men belonging to the control group, it will be highly relevant to compare with the HPV occurrence on sperm ejaculated from the men in concern.

A Linear Array HPV Genotyping Kit from Roche will be used for detection of HPV in testicular tissue and ejaculates. In total, with this test kit 37 HPV genotypes are examined for, including 13 high risk types.


Detailed Summary:
Sponsor: Odense University Hospital

Current Primary Outcome: HPV DNA in testicular tissue [ Time Frame: Two years ]

In tissue from both azoospermic and proven fertile men


Original Primary Outcome: Same as current

Current Secondary Outcome: HPV DNA in ejaculates [ Time Frame: Two years ]

In ejaculates from the proven fertile men


Original Secondary Outcome: Same as current

Information By: Odense University Hospital

Dates:
Date Received: December 29, 2014
Date Started: December 2014
Date Completion:
Last Updated: October 3, 2016
Last Verified: October 2016