Clinical Trial: System-IGF-1 Pathway and Alzheimer's Disease
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: A Multicenter Study to Assess Differences Between Circulating Levels of IGF-I and IGFBP-3 in Patients With Sporadic Late-onset Alzheimer's Disease and Control Elderly Subj
Brief Summary: The aim is to assess the relationship between levels of IGF-I system components and cognitive status in patients with Alzheimer's disease (AD), in elderly subjects with normal cognitive function, and in patients with mild cognitive impairment (MCI).
Detailed Summary:
AD is the most common cause of dementia. During aging, decline of biological brain functions due to a number of genetic and environmental factors facilitates the onset of AD. MCI includes prodromal AD.
The identification of the risk factors for AD must be a priority in order to define the best therapeutic approach.
Recent data support the notion that IGF-I pathway accounts for neuronal protection, with a dual effect, on both brain Aβ peptide and tau protein.
This large, multicenter, prospective, observational, cross-sectional population-based study in 3 parallel groups (200 participants per group) is aimed to assess differences between IGF-I and IGFBP3 circulating levels and polymorphisms in AD patients and control elderly subjects, and in MCI patients.
Sponsor: Assistance Publique - Hôpitaux de Paris
Current Primary Outcome: Circulating IGF-I and IGFBP-3 levels in AD patients and control elderly subjects at the time of assessment(T0). [ Time Frame: 24 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Circulating IGF-I and IGFBP-3 levels [ Time Frame: 24 hours ]
- Genetic polymorphisms in IGF-I / IGFBP-3 [ Time Frame: 24 hours ]
- Circulating IGF-I and IGFBP-3 levels and genetic polymorphisms in IGF-I / IGFBP-3 according to cognitive function. [ Time Frame: 24 hours ]
Original Secondary Outcome: Same as current
Information By: Assistance Publique - Hôpitaux de Paris
Dates:
Date Received: March 26, 2008
Date Started: October 2007
Date Completion:
Last Updated: June 5, 2013
Last Verified: June 2013