Clinical Trial: Conditioning Regimens for Patients With Severe Aplastic Anemia Transplanted With Marrow From an Unrelated Donor

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Conditioning Regimens for Patients With Severe Aplastic Anemia Transplanted With Marrow From an Unrelated Donor

Brief Summary: A single arm dose optimization study in which all patients are given a fixed dose of Cytoxan (4 x 50 mg/kg) plus ATG (3 x 30 mg/kg) and the TBI dose starting at 3 x 200 cGy is escalated or de-escalated dependent upon engraftment and toxicity.

Detailed Summary:
Sponsor: Fred Hutchinson Cancer Research Center

Current Primary Outcome: Sustained engraftment; survival

Original Primary Outcome: Same as current

Current Secondary Outcome: Acute and chronic GVHD

Original Secondary Outcome: Same as current

Information By: Fred Hutchinson Cancer Research Center

Dates:
Date Received: September 1, 2005
Date Started: May 1993
Date Completion:
Last Updated: April 28, 2008
Last Verified: April 2008