Clinical Trial: Anisakis Blastocystis Cryptosporidium Fish Prevalence

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Prevalence of Fish Allergy in Occupational Settings.

Brief Summary:

Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health.

Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or symptomatic, resulting in acute gastric, acute intestinal or chronic forms. Allergic manifestations are frequently encountered in gastric forms, but isolated allergic symptoms can occur after ingestion of Anisakidae antigens in raw or cooked fish. Cutaneous contact or Anisakis allergen inhalation have also been reported to induce allergy/anaphylactic reactions or sensitization in the occupational setting in Spain, Italy, Sicilia or South Africa. But no data is available in France.

In this context, the investigators propose to determine and compare the frequency and characteristics of fish allergy in fish workers (fishermen and fish-processing factory workers) and a control population of workers without occupational exposure to fish, in Boulogne-sur-Mer, which is an important fishing port in France, and the first European center for fish processing.

Detailed Summary: 162 fishermen, 162 fish-processing factory workers, and 162 control subjects will be consecutively recruited by their occupational doctor during a routine consultation. A standardized questionnaire will be used to collect epidemiological and clinical data on potential allergic manifestation resulting from digestive, cutaneous, or respiratory contact with fish. Domestic and occupational risk factors for fish and Anisakis exposure will also be collected for both allergic and non-allergic patients.
Sponsor: University Hospital, Lille

Current Primary Outcome: The prevalence of fish allergy [ Time Frame: contact by phone during 30 min at only visit (inclusion) ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Frequencies history of infections Anisakis spp. [ Time Frame: contact by phone during 30 min at only visit (inclusion) ]
  Comparison between occupationally exposed ( E: fishermen and fish-processing factory workers) and non-exposed subjects(NE)
• Frequency of fish allergies, history of infections Anisakis spp. (clinical diagnosis) [ Time Frame: contact by phone during 30 min at only visit (inclusion) ]

  comparison between occupationally exposed and non-exposed subjects for previous Anisakidosis.

  Fish exposure will be determined taking into account the handled fish species and the local prevalences of fish parasites.

• history of infections Anisakis spp. (clinical diagnosis) [ Time Frame: contact by phone during 30 min at only visit (inclusion) ]

  comparison between occupationally exposed and non-exposed subjects for previous Anisakidosis.

  Fish exposure will be determined taking into account the handled fish species and the local prevalences of fish parasites.

• Frequency of risk factors for occupational or domestic exposure to fish: [ Time Frame: contact by phone during 30 min at only visit (inclusion) ]
  comparison subjects (i) allergic or non-allergic Fish (APC + APC-vs) (ii) with or without a history of infection Anisakis spp. (IA + vs IA-).

Original Secondary Outcome: Same as current

Information By: University Hospital, Lille

Dates:
Date Received: January 13, 2016
Date Started: November 2014
Date Completion:
Last Updated: October 26, 2016
Last Verified: October 2016