Clinical Trial: Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis

Brief Summary: The purpose of this study was to evaluate long term efficacy and safety of topical ganciclovir treatment in Cytomegalovirus (CMV) anterior uveitis.

Detailed Summary:

The investigators will enroll 60 patients with positive results of the CMV PCR (polymerase chain reaction) from aqueous humor tapping from January 2006 to June 2011. All the patients (40 men, 20 women) were immunocompetent and diagnosed as symptomatic CMV infection. Their medical records will be reviewed, including demographic data as well as their ophthalmic and medical histories.

The purpose of this study was to evaluate long term efficacy and safety of topical ganciclovir treatment in CMV anterior uveitis.


Sponsor: National Taiwan University Hospital

Current Primary Outcome: Anterior chamber inflammation [ Time Frame: 4 weeks after starting treatment ]

anterior chamber cell grading based on slit lamp microscopy


Original Primary Outcome: Same as current

Current Secondary Outcome: probability of relapse-free [ Time Frame: 2 years after treatment ]

Kaplan-Meier curve of relapse-free probability


Original Secondary Outcome: Same as current

Information By: National Taiwan University Hospital

Dates:
Date Received: November 16, 2011
Date Started: October 2011
Date Completion: September 2012
Last Updated: December 5, 2011
Last Verified: December 2011