Clinical Trial: Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications

Brief Summary: Pathophysiology of Aortic Valve Stenosis remains poorly known. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design.

Detailed Summary: Aortic valve stenosis (AS) is the most common valvular disease and the second most common indication for cardiac surgery in Western countries. AS has long been considered as a passive and degenerative process. Recent data challenged this concept, showing that AS is an active and highly regulated process with some similarities to atherosclerosis. However, pathophysiology of AS remains poorly understood and preliminary data suggest that genetic factors may be involved. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design (1000 patients with AS and 1500 controls with no evidence of valve disease). For all patients and controls, blood samples including DNA and echocardiography will be performed.
Sponsor: Assistance Publique - Hôpitaux de Paris

Current Primary Outcome: Identification of genetic polymorphisms of fetuin-A, matrix-GLA protein, vitamin D receptor [ Time Frame: end of the study ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Identification of other genetic polymorphisms [ Time Frame: End of the Study ]

Original Secondary Outcome: Same as current

Information By: Assistance Publique - Hôpitaux de Paris

Dates:
Date Received: March 26, 2008
Date Started: March 2008
Date Completion: December 2017
Last Updated: February 27, 2017
Last Verified: February 2016