Clinical Trial: Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis
Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational
Official Title: Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis
Brief Summary: Calcified aortic valve stenosis (CAVS) is a progressive disease and nowadays, the cornerstone in diagnostics and follow-up is echocardiography. Cardiac biomarkers (such as cardiac troponins T and I and NT-pro-BNP) hold promise to fulfil a role in early recognition of complications concerning the aortic valve and decompensation. For this purpose, it is important to assess the normal biological variation (BV) of cardiac biomarkers in CAVS. The assessment of biological variation will contribute to a better understanding of fluctuation of cardiac biomarkers in subjects with stable CAVS. These data will improve monitoring of CAVS using cardiac biomarkers.
Detailed Summary:
Sponsor: Maastricht University Medical Center
Current Primary Outcome:
- Cardiac troponin T [ Time Frame: One year ]
- Cardiac troponin I [ Time Frame: One year ]
- NT-pro-BNP [ Time Frame: One year ]
Original Primary Outcome: Cardiac biomarkers [ Time Frame: One year ]
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Maastricht University Medical Center
Dates:
Date Received: July 27, 2015
Date Started: August 2015
Date Completion: October 2017
Last Updated: March 21, 2017
Last Verified: September 2016
