Clinical Trial: Dynamic MRI and Quantitative MR CSF Flow Studies in Craniovertebral Junction Anomalies

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Dynamic Magnetic Resonance Imaging (MRI) and Quantitative MR Cerebral Spinal Fluid (CSF) Flow Studies in Craniovertebral Junction Anomalies

Brief Summary: The purpose of this study is to decide which position of the neck affects cerebral spinal fluid (CSF) flow between the spinal cord and the brain. CSF is a fluid that flows up and down your spinal cord, around the brain and into the ventricles of the brain.

Detailed Summary: To perform dynamic cervical magnetic resonance imaging (MRI) of the craniovertebral junction (CVJ) coupled with CSF flow studies to assess changes in CSF flow velocities with changing position of the neck at the CVJ and aqueduct of Sylvius in patients with Chiari 1 malformations and similar malformations fo the CVJ leading to inherent instability in this region, and determine if there is any correlation of these findings to clinical outcome.
Sponsor: University of Michigan

Current Primary Outcome: To compare changes in flow velocities at the CVJ and aqueduct of Sylvius w/dynamic imaging in normal controls and in patients with symptomatic and asymptomatic Chiari 1 malformations and similar anomalies. [ Time Frame: 1 year ]

Original Primary Outcome: To compare changes in flow velocities at the CVJ and aqueduct of Sylvius w/dynamic imaging in normal controls and in patients with symptomatic and asymptomatic Chiari 1 malformations and similar anomalies.

Current Secondary Outcome: Results from the primary outcome will be correlated with post operative changes in a subset of patients as a predictor for surgical outcomes. [ Time Frame: 1 year ]

Original Secondary Outcome: Results from the primary outcome will be correlated with post operative changes in a subset of patients as a predictor for surgical outcomes.

Information By: University of Michigan

Dates:
Date Received: November 20, 2008
Date Started: July 2012
Date Completion: December 2018
Last Updated: February 8, 2017
Last Verified: February 2017