Clinical Trial: Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of
Brief Summary: Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.
Detailed Summary:
Sponsor: Tao Zhang
Current Primary Outcome: Number of patients with postoperative cognitive dysfunction [ Time Frame: 7 days after surgery ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Number of patients with postoperative cognitive dysfunction [ Time Frame: 3 months after surgery ]
- Changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6 (a composite outcome measure) [ Time Frame: 3 days after surgery ]
Original Secondary Outcome: Same as current
Information By: First Affiliated Hospital, Sun Yat-Sen University
Dates:
Date Received: March 25, 2014
Date Started: February 2014
Date Completion:
Last Updated: April 23, 2017
Last Verified: April 2017
