Clinical Trial: Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen

Brief Summary: There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements like zinc. Zinc in human seminal plasma was divided into three types of ligands which are high (HMW), intermediate (IMW), and low molecular weight ligands (LMW). The present study was conducted to study the effect of Zn supplementation on the quantitative and qualitative characteristics of semen along with Zinc Binding Protein levels in semen of patients with asthenozoospmia.

Detailed Summary: Elevation of ROS levels lead to an increase the oxidation of HMW-Zn binding proteins in seminal plasma of asthenozoospermic subjects. Zinc supplementation restores HMW-Zn% in seminal plasma of asthenozoospermic subjects to normal value. LMW-Zn% is elevated in seminal plasma of asthenozoospermic patients. It may be because increment the levels of semenogelin in seminal plasma of asthenozoospermic subjects. Zinc supplementation elevates LMW-Zn% in seminal plasma of asthenozoospermic subjects to more than normal value, this may be because of its enhancement of the synthesis of metallothioneins (Low molecular weight zinc binding protein).
Sponsor: mahmoud hussein hadwan

Current Primary Outcome: high molecular weight zinc binding protein [ Time Frame: at the end of three months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: qualitative semen parameters [ Time Frame: at the end of three months ]

Original Secondary Outcome: Same as current

Information By: Babylon University

Dates:
Date Received: June 1, 2012
Date Started: July 2011
Date Completion:
Last Updated: June 5, 2012
Last Verified: June 2012