Clinical Trial: Origin of Premature Atrial Beats Induced by Simulated Obstructive Sleep Apnea
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: Electroanatomic Origin of Premature Atrial Beats in Patients With Paroxysmal Atrial Fibrillation Induced by Intra-thoracic Pressure Swings Simulating Obstructive Sleep Apn
Brief Summary: There is accumulating evidence for obstructive sleep apnea (OSA) as an independent risk factor for paroxysmal atrial fibrillation and for high recurrence rates of atrial fibrillation after ablation therapy. We have previously shown that simulated OSA triggers premature atrial beats (PABs) by acute changes in intra-thoracic pressure. Most episodes of atrial fibrillation are initiated by PABs. However, the origin of PABs induced by intra-thoracic pressure swings is unknown. This study investigates the origin of premature atrial beats induced by intra-thoracic pressure changes that simulate obstructive sleep apnea in patients with atrial fibrillation.
Detailed Summary:
Sponsor: University of Zurich
Current Primary Outcome: Electroanatomical origin of premature atrial beats [ Time Frame: Participants will be followed for the duration of pulmonary vein isolation, an expected average of 3 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Catheter-based pressure in the left atrium and pulmonary veins during intra-thoracic pressure changes [ Time Frame: Participants will be followed for the duration of pulmonary vein isolation, an expected average of 3 hours ]
Original Secondary Outcome: Same as current
Information By: University of Zurich
Dates:
Date Received: October 14, 2014
Date Started: September 2014
Date Completion:
Last Updated: October 24, 2016
Last Verified: October 2016